Higher mortality rates were observed among unvaccinated persons during all three periods of Omicron lineage predominance ( Table). Mortality rates among adults aged ≥65 years peaked in December 2022 during the BQ.1/BQ.1.1 predominance period. Overall, 58% of deaths occurred among adults aged ≥80 years this distribution was consistent among vaccinated and unvaccinated persons and across the three variant periods. jurisdictions were reported during September 18, 2022–April 1, 2023. †††Īmong adults aged ≥65 years who were unvaccinated or had received a bivalent COVID-19 vaccine booster dose, 8,161 COVID-19–associated deaths in the 20 U.S.
This activity was reviewed by CDC and was conducted consistent with applicable federal law and CDC policy.
CDC DEATHS FROM COVID VACCINE SOFTWARE
SAS (version 9.4 SAS Institute) and R (version 4.1.2 R Foundation) software were used to conduct all analyses. RRs were calculated by dividing rates among unvaccinated persons by rates among bivalent booster dose recipients after detrending the underlying linear changes in weekly rates, 95% CIs were estimated from the remaining variation in rates observed*** ( 1). Average weekly mortality rates were estimated based on date of specimen collection ¶¶ during each variant period by vaccination status and time since bivalent booster dose receipt. intercensal population estimates, †† with numbers of unvaccinated persons estimated by subtracting numbers of vaccinated persons from the 2019 intercensal population estimates, as previously described §§ ( 1). Rate denominators were calculated from vaccine administration data and 2019 U.S. Vaccinated persons who did not receive a bivalent COVID-19 booster dose were excluded.
CDC DEATHS FROM COVID VACCINE REGISTRATION
jurisdictions** that routinely link case surveillance data to immunization registries and vital registration databases ( 1). †ĭuring September 18, 2022–April 1, 2023, weekly counts of COVID-19–associated deaths § among unvaccinated persons and those who received a bivalent booster dose ¶ were reported from 20 U.S. In this follow-up report on the durability of bivalent booster protection against death among adults aged ≥65 years, mortality rate ratios (RRs) were estimated among unvaccinated persons and those who received a bivalent booster dose by time since vaccination during three periods of Omicron lineage predominance (BA.5, BQ.1/BQ.1.1, and XBB.1.5 ). Updated (bivalent) COVID-19 vaccines were first recommended by CDC on September 1, 2022.* An analysis of case and death rates by vaccination status shortly after authorization of bivalent COVID-19 vaccines showed that receipt of a bivalent booster dose provided additional protection against SARS-CoV-2 infection and associated death ( 1). Scobie, PhD 1 ( View author affiliations) View suggested citation Turner, PhD 19 Caleb Wiedeman, MPH 26 Benjamin J. Khan, MPH 6 Anna Klioueva, MPH 20 Ruth Link-Gelles, PhD 1 Shelby Lyons, MPH 21 Joshua Mansfield, MSPH 21 Amanda Markelz, MPH 22 John Masarik III, MPH 23 Erica Mendoza, MAS 20 Keeley Morris, MPH 22 Enaholo Omoike, MD 16 Sai Paritala, Pharm.D 11 Komal Patel, MPH 2 Melissa Pike, MPH 15 Xandy Peterson Pompa, MPH 17 Kevin Praetorius, MSc 24 ,25 Nadine Rammouni, MPH 26 Hilda Razzaghi, PhD 27 Alexa Riggs, MPH 9 Minchan Shi, MS 1 Nekabari Sigalo, PhD 13 ,14 Emma Stanislawski, MPH 24 Buddhi P.
Hodis, MPH 1 Mikhail Hoskins, MPH 12 Amanda Jones, MPH 18 FNU Kanishka, MPH 10 Ramandeep Kaur, PhD 11 Samantha Kirkendall, MS 19 Saadiah I. Davidson, PhD 11 Yi Du, PhD 10 Aaron Fleischauer, PhD 12 Victoria Force, MS 4 Darren Frank, MPH 7 Ross Hamilton 13 ,14 Kaitlin Harame, MPH 15 Pauline Harrington, MPH 16 Liam Hicks, MPH 17 Jeffrey D. Bayoumi, DrPH 6 Sarah Bennett 7 Rachelle Boulton, MSPH 8 Carolyn Chang, MPH 9 Abigail Collingwood, MPH 8 Kevin Cueto, MS 10 Sherri L. Ali, MPH 1 Vanessa Aden, MPH 2 Brandy Armstrong 3 Brett Armstrong 3 Steven Auche, MPH 4 ,5 Nagla S. Johnson, DrPH 1 Lauren Linde, MPH 1 Amanda B.
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